New Antibiotic from Soil Bacteria

Researchers have isolated a new kind of antibiotic from a previously unknown and uncultured bacterial genus.

Written byAnna Azvolinsky
| 3 min read

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Ichip being removed from soilNORTHEASTERN UNIVERSITY, SLAVA EPSTEIN

Many of the most widely used antibiotics have come out of the dirt. Penicillin came from Penicillium, a fungus found in soil, and vancomycin came from a bacterium found in dirt. Now, researchers from Northeastern University and NovoBiotic Pharmaceuticals and their colleagues have identified a new Gram-positive bacteria-targeting antibiotic from a soil sample collected in Maine that can kill species including methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. Moreover, the researchers have not yet found any bacteria that are resistant to the antibiotic, called teixobactin. Their results are published today (January 7) in Nature.

“When we saw no resistance [to the compound], my first reaction was that we had discovered junk that would be highly toxic,” said microbiologist Kim Lewis, director of Northeastern’s Antimicrobial Discovery ...

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    Anna Azvolinsky received a PhD in molecular biology in November 2008 from Princeton University. Her graduate research focused on a genome-wide analyses of genomic integrity and DNA replication. She did a one-year post-doctoral fellowship at Memorial Sloan Kettering Cancer Center in New York City and then left academia to pursue science writing. She has been a freelance science writer since 2012, based in New York City.

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