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Self-Experimentation in the Time of COVID-19

Scientists are taking their own vaccines, an ethically murky practice that has a long and sometimes celebrated history in medicine.

Written byAmanda Heidt
| 6 min read
vaccine, Covid-19, coronavirus, SARS-CoV-2, pandemic, self experimentation, polio, poliovirus, yellow fever, Jonas Salk, Joseph Goldberger, George Church

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ABOVE: © ISTOCK.COM, MARY HERRON

Long before there were rumors of COVID parties (decline your invitation), there were actual “filth parties,” and the guest list was exclusive. Joseph Goldberger, an infectious disease expert in the US Public Health Service, was tasked in 1914 with determining the cause of pellagra, a systemic disease known for its four Ds—dermatitis, diarrhea, dementia, and death.

Many physicians at the time believed pellagra stemmed from an unknown germ, but Goldberger felt strongly, correctly, that it was the result of a nutritional deficiency. To prove it, he and his wife Mary held small gatherings during which they and a few brave volunteers injected themselves with the blood of pellagra victims and ate the feces and urine of patients in pill form, what Mary called “the most nauseating diabolical concoctions,” according to a 2014 book detailing Joseph’s work. Goldberger repeated this spectacle multiple times in cities through ...

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Meet the Author

  • amanda heidt

    Amanda first began dabbling in scicom as a master’s student studying marine science at Moss Landing Marine Labs, where she edited the student blog and interned at a local NPR station. She enjoyed that process of demystifying science so much that after receiving her degree in 2019, she went straight into a second master’s program in science communication at the University of California, Santa Cruz. Formerly an intern at The Scientist, Amanda joined the team as a staff reporter and editor in 2021 and oversaw the publication’s internship program, assigned and edited the Foundations, Scientist to Watch, and Short Lit columns, and contributed original reporting across the publication. Amanda’s stories often focus on issues of equity and representation in academia, and she brings this same commitment to DEI to the Science Writers Association of the Rocky Mountains and to the board of the National Association of Science Writers, which she has served on since 2022. She is currently based in the outdoor playground that is Moab, Utah. Read more of her work at www.amandaheidt.com.

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