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bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Engineering the Microbiome: CRISPR Leads the Way
Engineering the Microbiome: CRISPR Leads the Way

Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

genome editing

TK
Infographic: Engineering Microbiomes with CRISPR
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 2 min read
Researchers are using CRISPR for precise genetic manipulation of human-associated microbes as a promising avenue for improving human health.
A blue background with colorful illustrated viral particles
Delivering Prime Editors With Virus-like Particles
Deanna MacNeil, PhD | Mar 11, 2024 | 3 min read
An iterative engineering approach to improve prime editor delivery helped scientists correct genetic vision defects in mice.
Conceptual vector illustration depicting CRISPR gene editing by scientists for medical applications.
Optimizing Gene Editing with PARP1 CRISPR Plasmids 
The Scientist and Santa Cruz Biotechnology, Inc. | 3 min read
CRISPR plasmids provide a robust solution for streamlining human cell transfection workflows.   
Samantha Maragh speaks on stage after receiving the State of Maryland Outstanding Young Scientist Award 2019.
Making Standards Exceptional
Meenakshi Prabhune, PhD | Dec 4, 2023 | 9 min read
Samantha Maragh has taken on the difficult challenge of standardizing assays, data norms, and terminology in the ever evolving genome editing field.
This shows a cryo-EM map of a Fanzor protein in complex with its guiding RNA (in purple) and DNA (target strand in red, complementary strand in blue).
CRISPR-like Abilities in Eukaryotic Proteins
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
Two groups independently discovered that Fanzor proteins in eukaryotic organisms are CRISPR’s genome-editing cousins.
David Liu
Targeting a Genetic Accident to Treat Disease
Deanna MacNeil, PhD | 2 min read
David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
Using Genetics and Genomics to Improve Food Security
The Scientist | 1 min read
Pamela Ronald and Kan Wang will discuss how they enhance the yield and disease resistance of important crops.
untitled-design
From Bench to Boardroom
Aparna Nathan, PhD | Oct 25, 2021 | 5 min read
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
cartoon depiction of a pair of scissors about to cut a DNA double helix
Researchers Uncover New Families of Gene-Editing Enzymes
Annie Melchor | Sep 15, 2021 | 2 min read
The results reveal evolutionary relatives of the Cas9 enzyme now used extensively in biotechnology.
Laptop displays CRISPR poster.
The Next Generation of CRISPR-Cas Systems
Nathan Ni, PhD | 1 min read
Researchers reinvent genome editing with new CRISPR-Cas systems.
cartoon showing a hand taking a tool to a double-helix of DNA to represent gene editing
WHO Releases New Recommendations on Human Genome Editing
Annie Melchor | Jul 12, 2021 | 3 min read
The guidance comes after two years of consulting with hundreds of stakeholders, including indigenous peoples, religious leaders, patient groups, and scientists.
CRISPR, Cas-9, Nobel, Chemistry
CRISPR’s Adaptation to Genome Editing Earns Chemistry Nobel
Amanda Heidt | Oct 7, 2020 | 4 min read
Emmanuelle Charpentier and Jennifer Doudna reprogrammed the bacterial immune response into one of the most popular tools for genetics and molecular biology.
CRISPR Biosensors for Disease Diagnostics
The Scientist | 1 min read
Kiana Aran and Can Dincer will discuss potential advantages and diagnostic applications of CRISPR biosensing.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020 | 2 min read
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
crispr-cas9 duplications off-target effects insertions knock-ins
CRISPR Can Create Unwanted Duplications During Knock-ins
Katarina Zimmer | Feb 19, 2020 | 5 min read
A new study in mice documents frequent undesirable repeats of DNA insertions that are not detected using standard PCR analysis.
CRISPR Technologies for the New Era of Cell and Gene Therapy
The Scientist | 1 min read
Experts will discuss how they use new CRISPR technologies to advance their cell and gene therapy research.
Ten Minute Sabbatical
The Scientist | Jan 13, 2020 | 2 min read
Take a break from the bench to puzzle and peruse.
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