New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

genome editing
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Ashley Yeager | Sep 6, 2018
Using bioinformatics, two teams of scientists identified inhibitory proteins for Cas9’s relative.
Early Results of First In Vivo Gene-Editing Trial Encouraging
Early Results of First In Vivo Gene-Editing Trial Encouraging
Kerry Grens | Sep 5, 2018
Two patients who received Sangamo’s zinc finger–based treatment for Hunter syndrome have lower biomarkers of the condition, but no signs of new enzyme production.
US Companies Launch CRISPR Clinical Trial
US Companies Launch CRISPR Clinical Trial
Catherine Offord | Sep 3, 2018
The Germany-based study will test an ex vivo genome-editing therapy for the inherited blood disorder β-thalassemia.
Gene Editing Reduces Monkeys’ Cholesterol
Gene Editing Reduces Monkeys’ Cholesterol
Ashley Yeager | Jul 10, 2018
The results could lead to a treatment to lower cholesterol in patients with hypercholesterolemia.
CRISPR Efficiency Tied to Cancer-Causing Process
CRISPR Efficiency Tied to Cancer-Causing Process
Kerry Grens | Jun 11, 2018
Two studies find the genome-editing technique works best when cells have a faulty DNA-damage response that’s frequently present in cancers.  
New Methods to Detect CRISPR Off-Target Mutations
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
Immunity May Make CRISPR-Based Therapies Ineffective
Immunity May Make CRISPR-Based Therapies Ineffective
Jim Daley | Jan 10, 2018
Researchers identify antibodies for two commonly used Cas9 proteins in human blood. Investors take notice.
Meet the Press, 1967
Meet the Press, 1967
Kerry Grens | Dec 1, 2017
Fifty years ago, Arthur Kornberg announced to reporters that his team had synthesized functional DNA.
2017 Top 10 Innovations
2017 Top 10 Innovations
The Scientist Staff | Dec 1, 2017
From single-cell analysis to whole-genome sequencing, this year's best new products shine on many levels.