The Biggest Science News of 2018
The Biggest Science News of 2018
From disastrous scientific setbacks to the upending of scientific dogma and the end of a 40-year search for a protein
The Biggest Science News of 2018
The Biggest Science News of 2018

From disastrous scientific setbacks to the upending of scientific dogma and the end of a 40-year search for a protein

From disastrous scientific setbacks to the upending of scientific dogma and the end of a 40-year search for a protein

genome editing
CRISPR Scientists Slam Methods Used on Gene-Edited Babies
CRISPR Scientists Slam Methods Used on Gene-Edited Babies
Katarina Zimmer | Dec 4, 2018
Since He Jiankui presented his results at last week’s gene editing summit, researchers have raised concerns about his protocol, calling the procedure “amateurish” and “unconscionable.”
Opinion: Don’t Ban the Use of CRISPR in Embryos
Opinion: Don’t Ban the Use of CRISPR in Embryos
John D. Loike | Nov 29, 2018
Despite a premature and ethically sketchy claim of genome editing in twin girls, an outright prohibition could blunt promising, responsible progress.
Second CRISPR-Modified Pregnancy May Be Underway
Second CRISPR-Modified Pregnancy May Be Underway
Ashley P. Taylor | Nov 28, 2018
He Jiankui, who reportedly edited the genomes of two babies already, broke the news at a conference in Hong Kong.
Claim of First Gene-Edited Babies Triggers Investigation
Claim of First Gene-Edited Babies Triggers Investigation
Catherine Offord | Nov 26, 2018
He Jiankui says he has successfully used CRISPR-Cas9 to tweak the genes of twins born earlier this month. Some independent experts are dubious.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
Abby Olena | Sep 12, 2018
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Ashley Yeager | Sep 6, 2018
Using bioinformatics, two teams of scientists identified inhibitory proteins for Cas9’s relative.
Early Results of First In Vivo Gene-Editing Trial Encouraging
Early Results of First In Vivo Gene-Editing Trial Encouraging
Kerry Grens | Sep 5, 2018
Two patients who received Sangamo’s zinc finger–based treatment for Hunter syndrome have lower biomarkers of the condition, but no signs of new enzyme production.
US Companies Launch CRISPR Clinical Trial
US Companies Launch CRISPR Clinical Trial
Catherine Offord | Sep 3, 2018
The Germany-based study will test an ex vivo genome-editing therapy for the inherited blood disorder β-thalassemia.
Gene Editing Reduces Monkeys’ Cholesterol
Gene Editing Reduces Monkeys’ Cholesterol
Ashley Yeager | Jul 10, 2018
The results could lead to a treatment to lower cholesterol in patients with hypercholesterolemia.