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Enhancing Protein Engineering: Site Saturation Variant Libraries
Scientists compared protein engineering with a synthetic library versus error-prone PCR to achieve better variant representation and simpler validation.
Enhancing Protein Engineering: Site Saturation Variant Libraries
Enhancing Protein Engineering: Site Saturation Variant Libraries

Scientists compared protein engineering with a synthetic library versus error-prone PCR to achieve better variant representation and simpler validation.

Scientists compared protein engineering with a synthetic library versus error-prone PCR to achieve better variant representation and simpler validation.

GPCR

Identifying Antibodies that Target Membrane Proteins in Their Native Conformations
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A new mammalian display platform enhances antibody discovery for challenging protein targets.
Chemogenetics Doesn’t Work Like Many Thought
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A study finds the so-called DREADD method of manipulating neurons using a drug called CNO actually works via clozapine.
Discoverer of G Proteins Dies
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Nobel laureate Alfred Gilman has passed away at age 74.
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Light-Operated Drugs
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Scientists create a photosensitive pharmaceutical to target a glutamate receptor.
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Researchers are beginning to study in depth the largely uncharted territory of the eye’s microbial composition.
An Insoluble Problem?
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The challenges of crystallizing membrane proteins—and how they’re being overcome.
Bitter Pill
Richard P. Grant | Mar 1, 2011 | 2 min read
Editor's choice in drug discovery
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