The Next Generation of Noninvasive Brain Stimulation

New techniques for activating or suppressing neural activity by zapping the skull’s surface allow researchers to target smaller and deeper areas of the brain.

Written byJef Akst
| 3 min read

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ISTOCK, COSMIN4000Methods for manipulating brain activity are getting better by the day, it seems. From electrical and magnetic stimulation to optical and ultrasonic neural control, researchers are refining techniques to not only study the brain in animal models, but to possibly treat neurodegenerative diseases in humans as well.

“It’s the tools themselves that are really changing the face of what’s possible,” Helen Mayberg of Emory University School of Medicine said at a press conference at the Society for Neuroscience (SfN) meeting yesterday (November 14). She predicts that over the next few years, the field will see “an explosion in how to leverage these emerging technologies.”

As a demonstration of one potential application, John Walker of Northwestern University described recent work in which he and his colleagues used transcranial magnetic stimulation (TMS) to improve associative memory in healthy older adults, extending previous work showing the technique’s effectiveness in younger individuals. Walker and his colleagues used the noninvasive technique to stimulate the lateral parietal lobe, a surface-level brain region with high connectivity to the hippocampus, ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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