Here’s how guide RNAs and the Cas9 enzyme work together to edit DNA.
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The guide RNA (gRNA) forms a complex with Cas and directs the enzyme to cleave the target DNA to which the gRNA binds through complementary sequence. The cell tries to repair the DNA break, which often results in the insertion (as shown) or deletion of nucleotides that changes the reading frame of the gene and a creates premature stop codon.
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A citizen science game explores how social choices and networks can influence how an illness moves through a population.
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