Isolating Genomes from the Masses

Researchers find a way to determine the sequence of a single species from metagenomics data of entire microbial communities.

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Puget Sound, WashingtonWIKIMEDIA COMMONS, KATHY CALM

Metagenomics is the practice of taking a sample—a scoop of dirt or a cup of seawater—and sequencing all the DNA within. The technique helps researchers estimate the diversity of organisms found in a given environment, but until now, it wasn’t effective at sequencing individual species because there was no way to parse apart the data.

But a new computational approach published yesterday (February 2) in Science may provide the answer and allow researchers to sequence individual genomes from metagenomic data. The researchers applied their method to water samples taken from the surface of the Puget Sound, and were able to extract two complete genomes from a slurry of DNA from 14 different organisms.

“Our approach is exciting because it finally opens up a window to ...

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Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
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