Isolating Genomes from the Masses

Researchers find a way to determine the sequence of a single species from metagenomics data of entire microbial communities.

Written byJef Akst
| 1 min read

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Puget Sound, WashingtonWIKIMEDIA COMMONS, KATHY CALM

Metagenomics is the practice of taking a sample—a scoop of dirt or a cup of seawater—and sequencing all the DNA within. The technique helps researchers estimate the diversity of organisms found in a given environment, but until now, it wasn’t effective at sequencing individual species because there was no way to parse apart the data.

But a new computational approach published yesterday (February 2) in Science may provide the answer and allow researchers to sequence individual genomes from metagenomic data. The researchers applied their method to water samples taken from the surface of the Puget Sound, and were able to extract two complete genomes from a slurry of DNA from 14 different organisms.

“Our approach is exciting because it finally opens up a window to ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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