Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
ABOVE: © ISTOCK.COM, KOTO_FEJA
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Study Nearly Doubles Known Cancer-Linked Mutational Signatures

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

ABOVE: © ISTOCK.COM, KOTO_FEJA

DNA sequencing

Blue-toned illustration of the DNA double helix, with additional DNA strands in the background
Nearly Complete Human Genome Sequenced
Jef Akst | Jun 8, 2021
In a preprint, researchers fill in some of the holes left in the first draft of the human genetic code, published at the turn of the century.
Q&A: George Church’s Genome Up for Auction
Jef Akst | Apr 19, 2021
A founder of the field of synthetic biology is selling data from his own DNA as a nonfungible token, or NFT, through Nebula Genomics, a personal genome company he cofounded.
Scaling BAC on Time and Sample
The Scientist Creative Services Team in collaboration with Agilent Technologies | Apr 9, 2021
A new and simplified quality control method confirms the cloning of both small and large inserts in bacterial artificial chromosomes (BACs) with significantly less time and sample.
Bryan Sykes, Ancestral Genetics Expert, Dies at 73
Lisa Winter | Jan 12, 2021
Sykes sequenced famous ancient remains, such as Ötzi and Cheddar Man, and was one of the first researchers to use mitochondrial DNA to trace genetic lineages.
Y Chromosome from Early Modern Humans Replaced Neanderthal Y
Jef Akst | Sep 24, 2020
A selective advantage may have led the modern human Y chromosome to sweep through the Neanderthal population after it was introduced via interbreeding more than 100,000 years ago.
The Scientist Speaks Ep. 16 - At the Breaking Point: Mitochondrial Deletions and the Brain
The Scientist Creative Services Team | Mar 31, 2021
Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.
Gene Splicing Pioneer Dale Kaiser Dies
Ashley Yeager | Jun 29, 2020
Working with a virus that infects bacteria, the Stanford University biochemist and developmental biologist helped to develop a way to stitch DNA together, a discovery that gave rise to genetic engineering.
Joachim Messing in a greenhouse with corn
Joachim Messing, Developer of Shotgun Sequencing, Dies
Shawna Williams | Oct 1, 2019
In addition to his work on widely-used techniques, the researcher was known for engineering crop plants.
One Size Does Not Fit All: Pharmacogenomics in Precision Medicine
The Scientist Creative Services Team | Feb 10, 2021
Sandosh Padmanabhan and Andrew Morrow will discuss how pharmacogenomics methods improve precision medicine for cardiovascular disease treatment.
Ancient Genomes Reveal Clues About Native Americans’ Past
Jef Akst | Jun 6, 2019
Sequences from dozens of ancient remains from Siberia reveal the closest ancient relative of Native Americans found outside of North America.
The Human Genetics of Night Owls and Early Birds
Jef Akst | Jan 31, 2019
When people prefer to go to bed is linked to hundreds of variations in their genes.
Advances in Nucleic Acid Sequencing
The Scientist Creative Services Team | Aug 13, 2020
Download this eBook to learn how new sequencing methods revolutionize genetics research!
Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
Catherine Offord | Dec 14, 2018
The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.
Genetic Sequencing Uncovers New Options for Multiple Myeloma Patients
Shawna Williams | Nov 1, 2018
A small pilot study suggests the approach can identify effective treatments already approved for other cancers.
Genome, Exome, RNA Sequencing Applied to Pediatric Cancer Cases
Ashley Yeager | Oct 18, 2018
Combining data from the genetic testing techniques can guide patient care, scientists say.
Massive Animal Sequencing Effort Releases First Set of Genomes
Jef Akst | Sep 13, 2018
The Vertebrate Genomes Project has released data on 14 vertebrate species, but the goal is to sequence all 66,000.
Companies to Help People Sell or Rent Out Their Health Data
Catherine Offord | Jun 5, 2018
Luna DNA, Nebula Genomics, and other “bio-brokers” will allow customers to make money by granting access to their genetic and personal information for research purposes.
Surveying Biodiversity with Leeches
Diana Kwon | Jun 1, 2018
Scientists are searching for signatures of mammals within the blood meals of the invertebrates.
Meet the Leechmeister
The Scientist Staff | May 31, 2018
See the American Museum of Natural History curator Mark Sidall explain his fascination with leeches, which he and other scientists are using to infer biodiversity in some far-flung places.