Mapping the Neighborhoods of the Gut Microbiome

Researchers are going beyond fecal samples to understand how the patterns of commensal microbes in the gastrointestinal tract influence development and health.

Written byAbby Olena, PhD
| 7 min read
An image of part of a mouse distal colon showing luminal contents with bacteria in magenta, the mucus lining (green) and the epithelial cell barrier of the gut (blue, right).
Register for free to listen to this article
Listen with Speechify
0:00
7:00
Share

Dissecting wombats’ intestines isn’t the easiest way to get an idea about what’s happening with their gut microbiomes, yet that’s what University of Adelaide postdoc Raphael Eisenhofer and his colleagues did for a recent study. Collecting poop would have been easier—particularly for endangered species like wombats—but the researchers wanted more information than they could glean from a stool sample.

“We’ve been using feces for quite a long time now because they’re very easy to get, but what we know about microbial ecology is it’s all about location—where the microbes are in the interface of the host,” Eisenhofer explains.

He and his coauthors characterized the microbial biogeography, or the spatial information about what microbes are present where, of the gastrointestinal (GI) tracts of one bare-nosed wombat (Vombatus ursinus) and one southern hairy-nosed wombat (Lasiorhinus latifrons). Eisenhofer acknowledges the limitations of using just two wombats, yet the team still found some surprises.

...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • abby olena

    As a freelancer for The Scientist, Abby reports on new developments in life science for the website. She has a PhD from Vanderbilt University and got her start in science journalism as the Chicago Tribune’s AAAS Mass Media Fellow in 2013. Following a stint as an intern for The Scientist, Abby was a postdoc in science communication at Duke University, where she developed and taught courses to help scientists share their research. In addition to her work as a science journalist, she leads science writing and communication workshops and co-produces a conversational podcast. She is based in Alabama.  

    View Full Profile
Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Golden geometric pattern on a blue background, symbolizing the precision, consistency, and technique essential to effective pipetting.

Best Practices for Precise Pipetting

Integra Logo
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad

Products

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

The Scientist Placeholder Image

Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

OGT logo

OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel