A raccoon dog behind cage bars.
New Preprints Further Implicate Market in Pandemic’s Origins
Three studies that analyzed samples from Wuhan’s Huanan Seafood Wholesale Market add to evidence that SARS-CoV-2 has zoonotic origins.
ABOVE: © iStock.com, Viktor_Kitaykin
New Preprints Further Implicate Market in Pandemic’s Origins
New Preprints Further Implicate Market in Pandemic’s Origins

Three studies that analyzed samples from Wuhan’s Huanan Seafood Wholesale Market add to evidence that SARS-CoV-2 has zoonotic origins.

Three studies that analyzed samples from Wuhan’s Huanan Seafood Wholesale Market add to evidence that SARS-CoV-2 has zoonotic origins.

ABOVE: © iStock.com, Viktor_Kitaykin

viral vectors

a veterinarian in a white hazmat suit holding a small pig
The Long Journey to Resolve the Origins of a Previous Pandemic
Martha Nelson | Sep 2, 2021
Dozens of researchers, including myself, worked for years to uncover that swine flu had leapt to humans from a pig in Mexico in 2009. We learned a lot about influenza evolution, pig farming, and outbreak risk along the way.
An artistic rendering of blue neurons against a white background
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Exosomes, microvesicles, and apoptotic bodies: The three major types of extracellular vesicle.
Extracellular Vesicles: Applications and Potential
Beckman Coulter Life Sciences | May 13, 2022
Explore why extracellular vesicles are attractive candidates for new therapeutic approaches.
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Lisa Winter | Mar 11, 2021
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
Infographic: Trans-kingdom Interactions in the Gut
Catherine Offord | Feb 1, 2021
Phages interact with bacteria and eukaryotic cells in ways that researchers suspect influence mammalian health.
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Capturing Heterogeneity: How Single Cell Analysis Reshapes Health and Disease Research
The Scientist Creative Services Team | Sep 30, 2021
Timothy O’Sullivan and Jacob Blum will discuss how they use single cell data to understand complex biological systems.
Insects Pass Antiviral Immunity to Offspring
Abby Olena | Dec 17, 2020
In both Drosophila and mosquitoes, protection lasts for generations following a single maternal exposure to positive-sense single-stranded RNA viruses.
aav adeno-associated virus vector gene therapy antibody hemophilia
Thwarting AAV-Neutralizing Antibodies Could Improve Gene Therapy
Emma Yasinski | Sep 25, 2020
Adeno-associated viral vectors can deliver gene therapies, but AAV-neutralizing antibodies might prevent the medicines from working.
Form Determines Function: Insights from Structural Biology
The Scientist Creative Services Team | Jul 23, 2021
Researchers use diverse tools to analyze protein structures.
adenovirus vector vaccine covid-19 pandemic coronavirus sars-cov-2 spike protein
Vector-Based Vaccines Come to the Fore in the COVID-19 Pandemic
Anthony King | Sep 8, 2020
Adenovirus vectors deliver the genetic instructions for SARS-CoV-2 antigens directly into patients’ cells, provoking a robust immune response. But will pre-existing immunity from common colds take them down?
Dog Study Revives Concerns About Virus Used for Gene Therapy
Jef Akst | Jan 6, 2020
Canines treated with an adeno-associated viral (AAV) vector showed evidence that the therapeutic DNA held within the virus can integrate into the host genome, risking the activation of oncogenes.
Delivering Combination Immunotherapies to Solid Tumors
LabTalk Podcast - A Modern Trojan Horse: Delivering Combination Immunotherapies to Solid Tumors 
The Scientist Creative Services Team, IsoPlexis | Apr 26, 2021
Katie McKenna discusses a combination CAR T and viral therapy that kills solid tumors.
Adeno-associated viruses
Strategies for Smuggling Gene Therapies Past the Immune System
Monique Brouillette | Jul 15, 2019
Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.
Image of the Day: Ringspots
Carolyn Wilke | Jan 25, 2019
Tiny insects carry the tomato spotted wilt virus, which causes infected plants to develop discolored ring-shape blotches.
Optimizing Adeno-Associated Virus (AAV) Manufacturing
The Scientist Creative Services Team in collaboration with OXGENE | Feb 16, 2021
Scientists wield nature’s power to optimize adeno-associated virus (AAV) production and maximize gene therapy safety.
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
Catherine Offord | Aug 31, 2018
Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.
World’s Largest Cell and Gene Therapy Plant Opens
Catherine Offord | Apr 10, 2018
Lonza will employ more than 200 full-time staff to work at the Texas-based facility, the company says.
Laptop displays CRISPR poster.
The Next Generation of CRISPR-Cas Systems
Nathan Ni, PhD | Feb 4, 2021
Researchers reinvent genome editing with new CRISPR-Cas systems.
Severe Toxicity Reported in High-Dose AAV Gene Therapy in Animals
Jim Daley | Jan 31, 2018
Biotech stocks fell in response to the news.