Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds

Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.

Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.

viral vectors
Form Determines Function: Insights from Structural Biology
Form Determines Function: Insights from Structural Biology
The Scientist Creative Services Team | Jul 23, 2021
Researchers use diverse tools to analyze protein structures.
LabTalk Podcast - A Modern Trojan Horse: Delivering Combination Immunotherapies to Solid Tumors 
LabTalk Podcast - A Modern Trojan Horse: Delivering Combination Immunotherapies to Solid Tumors 
The Scientist Creative Services Team in Collaboration with IsoPlexis | Apr 26, 2021
Katie McKenna discusses a combination CAR T and viral therapy that kills solid tumors.
Optimizing Adeno-Associated Virus (AAV) Manufacturing
Optimizing Adeno-Associated Virus (AAV) Manufacturing
The Scientist Creative Services Team in collaboration with OXGENE | Feb 16, 2021
Scientists wield nature’s power to optimize adeno-associated virus (AAV) production and maximize gene therapy safety.
The Next Generation of CRISPR-Cas Systems
The Next Generation of CRISPR-Cas Systems
The Scientist Staff | Feb 4, 2021
Researchers reinvent genome editing with new CRISPR-Cas systems.
Infographic: Trans-kingdom Interactions in the Gut
Infographic: Trans-kingdom Interactions in the Gut
Catherine Offord | Feb 1, 2021
Phages interact with bacteria and eukaryotic cells in ways that researchers suspect influence mammalian health.
Accelerating Discovery in the Age of a Pandemic
Accelerating Discovery in the Age of a Pandemic
The Scientist Creative Services Team | Jan 22, 2021
An expert panel will present how synthetic biology accelerates the development of diagnostics, therapeutics, and the medicinal pipeline.
Insects Pass Antiviral Immunity to Offspring
Insects Pass Antiviral Immunity to Offspring
Abby Olena | Dec 17, 2020
In both Drosophila and mosquitoes, protection lasts for generations following a single maternal exposure to positive-sense single-stranded RNA viruses.
<em>The Scientist</em>&#39;s LabTalk - Episode 4
The Scientist's LabTalk - Episode 4
The Scientist Creative Services Team | Dec 11, 2020
The Past, Present, and Future of Gene Therapy: How to Scale-up Successfully
Thwarting AAV-Neutralizing Antibodies Could Improve Gene Therapy
Thwarting AAV-Neutralizing Antibodies Could Improve Gene Therapy
Emma Yasinski | Sep 25, 2020
Adeno-associated viral vectors can deliver gene therapies, but AAV-neutralizing antibodies might prevent the medicines from working.
Vector-Based Vaccines Come to the Fore in the COVID-19 Pandemic
Vector-Based Vaccines Come to the Fore in the COVID-19 Pandemic
Anthony King | Sep 8, 2020
Adenovirus vectors deliver the genetic instructions for SARS-CoV-2 antigens directly into patients’ cells, provoking a robust immune response. But will pre-existing immunity from common colds take them down?
Dog Study Revives Concerns About Virus Used for Gene Therapy
Dog Study Revives Concerns About Virus Used for Gene Therapy
Jef Akst | Jan 6, 2020
Canines treated with an adeno-associated viral (AAV) vector showed evidence that the therapeutic DNA held within the virus can integrate into the host genome, risking the activation of oncogenes.
Strategies for Smuggling Gene Therapies Past the Immune System
Strategies for Smuggling Gene Therapies Past the Immune System
Monique Brouillette | Jul 15, 2019
Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.
Image of the Day: Ringspots
Image of the Day: Ringspots
Carolyn Wilke | Jan 25, 2019
Tiny insects carry the tomato spotted wilt virus, which causes infected plants to develop discolored ring-shape blotches.
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
Catherine Offord | Aug 31, 2018
Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.
World’s Largest Cell and Gene Therapy Plant Opens
World’s Largest Cell and Gene Therapy Plant Opens
Catherine Offord | Apr 10, 2018
Lonza will employ more than 200 full-time staff to work at the Texas-based facility, the company says.
Severe Toxicity Reported in High-Dose AAV Gene Therapy in Animals
Severe Toxicity Reported in High-Dose AAV Gene Therapy in Animals
Jim Daley | Jan 31, 2018
Biotech stocks fell in response to the news. 
CRISPR Proves Promising for Treating ALS in Mice
CRISPR Proves Promising for Treating ALS in Mice
Katarina Zimmer | Dec 20, 2017
The gene-editing tool was effective in disabling a defective gene responsible for some forms of amyotrophic lateral sclerosis. 
Bacteria-Treated Mosquitoes Released in More Locations
Bacteria-Treated Mosquitoes Released in More Locations
Kerry Grens | Jan 17, 2017
Infected with Wolbachia, the insects are expected to reduce the spread of dengue and Zika. But scientists say the approach may have limitations.
A Method to Detect Zika-Blocking Bacteria
A Method to Detect Zika-Blocking Bacteria
Tanya Lewis | Jul 5, 2016
A team of scientists confirm Wolbachia can prevent mosquitoes from transmitting the virus, while another group finds a reliable way to detect the bacteria.