What’s the Deal with Bacterial Nanotubes?

Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?

Written bySruthi S. Balakrishnan
| 53 min read
A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.

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ABOVE: MICROBIAL CONNECTIONS: Nanotubes can be seen extending from E. coli in this scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi.
CHRISTIAN KOST, OSNABRÜCK UNIVERSITY

In 2011, the microbiology community learned of a brand-new feature of bacteria: nanotubes. Scientists later showed that these membranous, hollow connections between bacteria allow the transfer of materials such as amino acids and toxins that inhibit growth. These tubes were unlike anything the researchers had seen before: in contrast to the conjugative pili that transfer genetic material during bacterial “sex,” the nanotubes were made of lipids, not proteins. They were also more promiscuous than pili, often linking microbes of different species, and even connecting bacteria with mammalian cells. It was starting to look like bacterial nanotubes were long-overlooked features of microbiology.

Jiří Pospíšil, a graduate student at the Czech Academy of Sciences, was enamored with these novel bacterial structures—so much so that ...

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Meet the Author

  • Sruthi S. Balakrishnan is a freelance science writer based in Bangalore, India. After spending her doctoral days poking fruit flies in the eye, she realized that she preferred writing about science more than doing science. She finished her PhD and made the ol’ pipette-to-pen transition in 2019. She now writes about things such as kleptomaniacal sea slugs and ants that can control their own gut microbes. Follow her on Twitter @sruthisanjeev.

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