Isolating mitochondria from three cell types of the mouse cerebellum allowed researchers to look for differences in the organelles’ proteomes based on their cell type of origin. The experiments found many proteins that were differentially expressed in the mitochondria of Purkinje cells, granule cells, and astrocytes. Follow-up in vitro assays and in vivo imaging supported some of the functional implications of the proteomic findings.

© Kelly Finan

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Jef Akst is the managing editor of The Scientist. Email her at

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