Microscopic Robots Deliver Drugs to the Brain

Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.

Written byAsher Jones
| 5 min read
neutrobots, neutrophils, white blood cells, microrobots, nanorobots, microbots, glioma, brain cancer, paclitaxel, magnetic, swarm, mice

Register for free to listen to this article
Listen with Speechify
0:00
5:00
Share

ABOVE: Neutrobots stained purple
H. ZHANG ET AL., SCI ROBOT, 2021

Microscopic swimming robots that could navigate through the body to perform medical tasks such as delivery of targeted cancer therapies or surgeries are currently in development. In a study published March 24 in Science Robotics, scientists made magnetically controlled microrobots based on neutrophils, a type of white blood cell. In mice, these so-called neutrobots penetrated the blood-brain barrier (BBB) to deliver drugs to brain cancer cells.

“This is a very cool idea,” says Liangfang Zhang, a nanoengineer and bioengineer at the University of California, San Diego, who was not involved with the study. “I would say this paper is still an early proof-of-concept study, but I think that the overall concept is novel. It’s interesting because it’s new thinking about how to send cargo to the brain.”

A major hurdle in treating neurological diseases is getting drugs past the BBB, ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies