Zebrafish with parts of nervous system in green.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

drug discovery
headshot man
Ophthamologist Alan Scott Dies at Age 89
Chloe Tenn | Dec 29, 2021
The Smith-Kettlewell Eye Research Institute scientist developed Botox for medicinal use.
images related to COVID-19 pandemic, including sign reading "please keep your distance," illustration of the virus, various pills, vaccine syringes
What We Learned About COVID-19 in 2021
Shawna Williams | Dec 16, 2021
As Omicron induces a sense of deja vu at the close of the year, we look back at a few key ways in which our understanding has moved forward.
Don Ingber engineered cystic fibrosis airway chips that recapitulate patient symptoms.
A New Model of Lung Disease Paves the Way for Personalized Treatments
Nele Haelterman, PhD
Scientists engineered a lung-on-a-chip model from patient cells that mimics cystic fibrosis.
illustration of brain cells in blue with amyloid plaques in orange and pink immune cells
Excerpt from The Memory Thief
Lauren Aguirre | Jun 1, 2021
Author Lauren Aguirre finds reasons for optimism in the fight against Alzheimer’s disease.
How the Pharma Industry Pulled Off the Pivot to COVID-19
Diana Kwon | Jul 13, 2020
The urgent need for tests and therapeutics has brought companies together and pushed researchers to work at breakneck speeds.
Induced Pluripotent Stem Cells: Reprogramming and Applications
Technique Talk: Induced Pluripotent Stem Cells: Reprogramming and Applications
The Scientist Creative Services Team
Ritu Kumar will discuss how derivation of induced pluripotent stem cells from somatic cells has revolutionized regenerative medicine.
Gene Therapy Finds a Fertile Home in Ohio
Shawna Williams | Jan 13, 2020
The midwestern state has quietly laid the groundwork for a biotech hub.
a photo of ampules stored in wire racks
Scripps Acquires Pfizer’s Massive Microbial Library
Jef Akst | Jan 9, 2020
The East Coast campus of the research institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products.
Human DNA stock photo
Setting Better Traps for PARP Inhibitors
The Scientist Creative Services Team and BPS Bioscience
An innovative assay permits researchers to screen for small molecule PARP inhibitors that trap the enzyme on DNA and selectively execute cancer cells.
computing a cure
Artificial Intelligence Shakes Up Drug Discovery
Bianca Nogrady | May 1, 2019
The pharmaceutical industry is looking to machine learning to overcome complex challenges in drug development.
small-molecule therapeutics treat cancer and other diseases
Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs
Claire Asher | Apr 1, 2019
Renewed interest from the biotech industry sparks hope for drugging the nucleic acid to treat cancer and other conditions.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist Creative Services Team and Thermo Fisher Scientific
New technologies allow researchers to scale up assays for cellular functions.
Toxin from a Dangerous Fish Delicacy
Kerry Grens | Jan 1, 2018
In tiny doses, the pufferfish’s tetrodotoxin can be turned into a pain-relieving ion channel blocker.
Sourcing Painkillers from Scorpions’ Stings
Abby Olena | Jan 1, 2018
Compounds in the arachnids’ venom interact with ion channels to both cause and block pain.
40422-lt-highqualityscreening-800x560
High-Quality Screening and Target Validation During Drug Development
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific
Drew Adams will discuss his work developing therapeutics that promote remyelination for neurological diseases.
Sea Anemone Toxin Could Treat Autoimmunity
Jef Akst | Jan 1, 2018
If successful, the treatments could alleviate patients’ pain by reducing inflammation.
Frog Skin Yields Potent Painkillers, but None Clinic Ready
Shawna Williams | Jan 1, 2018
Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.
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DNA Unlocked - A Special 3-Part Q&A Series
The Scientist Creative Services Team in collaboration with Amgen
Dive deeper into the DNA Unlocked podcasts
Novel Analgesics at a Snail’s Pace
Bob Grant | Jan 1, 2018
Studying cone snail venom has yielded novel pain pathways, but the peptides that function as toxins are difficult to translate into drugs.